What does this research mean for the field?

Among heart failure patients meeting MADIT II criteria, microvolt T-wave alternans is superior to QRS duration for identifying both high-risk patients and low-risk patients unlikely to benefit from implantable cardioverter-defibrillator (ICD) therapy. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

September 28, 2004Circulation

Microvolt T-Wave Alternans Distinguishes Between Patients Likely and Patients Not Likely to Benefit From Implanted Cardiac Defibrillator Therapy

View Full Paper

Ask AI

Bookmark

Why the study?

Does microvolt T-wave alternans better predict 2-year mortality compared to QRS duration in heart failure patients meeting MADIT II criteria?

Population

177 heart failure patients with MADIT II characteristics and sinus rhythm

Comparison

Microvolt T-wave alternans exercise test vs 12-lead ECG QRS duration (>120 ms vs <=120 ms)

Design

Cohort

Follow-up

average 20+/-6 months

Authors

DBDaniel M. BloomfieldHeart Failure & Transplant RSRichard C. SteinmanColumbia University PNPearila Brickner NamerowRutgers, The State University of New Jersey

Discussion

Member takes

Implication

TWA may aid mortality risk stratification in MADIT II-like HF; leaves open whether it refines ICD selection.

Structured PICO

Does microvolt T-wave alternans better predict 2-year mortality compared to QRS duration in heart failure patients meeting MADIT II criteria?

Population

177 heart failure patients with MADIT II characteristics and sinus rhythm

Intervention

Microvolt T-wave alternans exercise test (abnormal vs normal)

Comparator

12-lead ECG QRS duration (>120 ms vs <=120 ms)

Outcome

2-year all-cause mortalityhard clinical

Microvolt T-wave alternans is superior to QRS duration for risk-stratifying MADIT II-like heart failure patients to identify those most and least likely to benefit from ICD therapy.

Cite This Study

Bloomfield et al. (2004) studied this question.

synapsesocial.com/papers/6a1e6c3240bc8a3dd768de5b https://doi.org/10.1161/01.cir.0000143160.14610.53

Topics

Cardiac device therapy Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Microvolt T-Wave Alternans Distinguishes Between Patients Likely and Patients Not Likely to Benefit From Implanted Cardiac Defibrillator Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Microvolt T-Wave Alternans Distinguishes Between Patients Likely and Patients Not Likely to Benefit From Implanted Cardiac Defibrillator Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider