Why the study?
Does insulin resistance alter the acute effect of insulin on arterial stiffness?
Does insulin resistance alter the acute effect of insulin on arterial stiffness?
Insulin resistance blunts the acute arterial stiffness-reducing effects of insulin, potentially linking insulin resistance to cardiovascular disease.
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Suggests a mechanism linking insulin resistance to vascular risk; hypothesis-generating and requires prospective confirmation.
Insulin resistance is associated with increased cardiovascular morbidity and mortality but the underlying mechanism(s) are incompletely understood. Epidemiological data suggest that insulin resistance and arterial stiffness are interrelated. In insulin sensitivesubjects, insulin acutely decreases the augmentation index as measured using pulse wave analysis. In insulin-resistant subjects, this effect of insulin is blunted implying that insulin resistance involves also large arteries. This may provide one mechanism linking insulin resistance and cardiovascular disease.
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Yki‐Järvinen et al. (2006) studied this question.
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