November 1, 2001The Journal of Clinical Endocrinology & MetabolismOpen Access

Resistance to Acute Insulin Induced Decreases in Large Artery Stiffness Accompanies the Insulin Resistance Syndrome

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Why the study?

Does acute insulin infusion decrease large artery stiffness in healthy men, and is this effect blunted in insulin resistance?

Population

50 healthy men, mean age 34 ± 2 years, mean body mass index 27 ± 1 kg/m2

Design

Other

Follow-up

240 minutes (two 120-minute infusions)

Authors

JWJ. WesterbackaUniversity of Helsinki

Discussion

Member takes

Implication

Acute insulin may reduce arterial stiffness; leaves open its relevance in insulin resistance and need for outcome trials.

Structured PICO

Does acute insulin infusion decrease large artery stiffness in healthy men, and is this effect blunted in insulin resistance?

Population

50 healthy men, mean age 34 ± 2 years, mean body mass index 27 ± 1 kg/m2

Intervention

2 sequential insulin infusions, each lasting 120 min (1 and 2 mU/kg·min)

Outcome

Change in augmentation index (AgI) as a measure of arterial stiffnesssurrogate

Physiological concentrations of insulin acutely decrease large artery stiffness, an effect that is blunted in states of insulin resistance such as obesity.

Cite This Study

J. Westerbacka (2001) studied this question.

synapsesocial.com/papers/6a72c1e8b27f158178281e38 https://doi.org/10.1210/jc.86.11.5262

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November 1, 2001The Journal of Clinical Endocrinology & MetabolismOpen Access

Resistance to Acute Insulin Induced Decreases in Large Artery Stiffness Accompanies the Insulin Resistance Syndrome

View Full Paper

Ask AI

Bookmark

Why the study?

Does acute insulin infusion decrease large artery stiffness in healthy men, and is this effect blunted in insulin resistance?

Population

50 healthy men, mean age 34 ± 2 years, mean body mass index 27 ± 1 kg/m2

Design

Other

Follow-up

240 minutes (two 120-minute infusions)

Authors

JWJ. WesterbackaUniversity of Helsinki

Discussion

Member takes

Implication

Acute insulin may reduce arterial stiffness; leaves open its relevance in insulin resistance and need for outcome trials.

Structured PICO

Does acute insulin infusion decrease large artery stiffness in healthy men, and is this effect blunted in insulin resistance?

Population

50 healthy men, mean age 34 ± 2 years, mean body mass index 27 ± 1 kg/m2

Intervention

2 sequential insulin infusions, each lasting 120 min (1 and 2 mU/kg·min)

Outcome

Change in augmentation index (AgI) as a measure of arterial stiffnesssurrogate

Physiological concentrations of insulin acutely decrease large artery stiffness, an effect that is blunted in states of insulin resistance such as obesity.

Cite This Study

J. Westerbacka (2001) studied this question.

synapsesocial.com/papers/6a72c1e8b27f158178281e38 https://doi.org/10.1210/jc.86.11.5262

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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