What does this research mean for the field?

Retrograde coronary venous infusion of ethanol effectively ablates ventricular myocardium and achieves transmural necrosis at volumes of 3 cc or more, without causing adverse hemodynamic effects or inducible ventricular tachycardia. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1998Journal of Cardiovascular Electrophysiology

Retrograde Coronary Venous Infusion of Ethanol for Ablation of Canine Ventricular Myocardium

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Why the study?

Does retrograde coronary venous infusion of ethanol effectively ablate ventricular myocardium in a canine model?

Population

9 anesthetized dogs

Comparison

Retrograde coronary venous infusion of pure… vs Baseline measurements (before ablation)

Design

Preclinical

Follow-up

1 week

Authors

KWKathy N. WrightThe Ohio State University TMTRACEY MORLEY JBJEANETTE L. BICKNELLUniversity of Alabama at Birmingham

Discussion

Member takes

Implication

Supports investigation of ethanol venous infusion for VT ablation; leaves open safety and efficacy in patients.

Structured PICO

Does retrograde coronary venous infusion of ethanol effectively ablate ventricular myocardium in a canine model?

Population

9 anesthetized dogs

Intervention

Retrograde coronary venous infusion of pure ethanol at volumes of 1.5, 3, or 5 cc using a balloon-tipped infusion catheter

Comparator

Baseline measurements (before ablation)

Outcome

Lesion volumes and histologic examination of ablation bedssurrogate

Retrograde coronary venous infusion of ethanol (≥3 cc) effectively produces transmural myocardial necrosis in a canine model without adverse hemodynamic effects, suggesting potential for VT ablation.

Cite This Study

Wright et al. (1998) studied this question.

synapsesocial.com/papers/6a1e70d2e6eabd489e68a937 https://doi.org/10.1111/j.1540-8167.1998.tb00138.x

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Retrograde Coronary Venous Infusion of Ethanol for Ablation of Canine Ventricular Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Retrograde Coronary Venous Infusion of Ethanol for Ablation of Canine Ventricular Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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