Key result
Direct intramyocardial ethanol injection resulted in noninducibility of ventricular tachycardia in 7 of 8 sheep 20 minutes after ablation.
Why the study?
Does catheter-based intramyocardial injection of ethanol prevent the inducibility of ventricular tachycardia in a sheep model of chronic myocardial infarction?
Does catheter-based intramyocardial injection of ethanol prevent the inducibility of ventricular tachycardia in a sheep model of chronic myocardial infarction?
Catheter-based intramyocardial injection of ethanol is feasible and effectively eliminates inducible VT in a sheep model of chronic myocardial infarction, offering a potential approach for deep intramyocardial or subepicardial ablation.
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May inform catheter-based chemoablation for intramural VT substrates; leaves open human translation pending clinical trials.
Reek et al. (2004) studied Ventricular tachycardia in chronic myocardial infarction (n=8). Catheter-based intramyocardial injection of ethanol, glycerine, and iopromide was evaluated on Noninducibility of any ventricular tachycardia 20 minutes after ablation. Direct intramyocardial ethanol injection resulted in noninducibility of ventricular tachycardia in 7 of 8 sheep 20 minutes after ablation.
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