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January 1, 1996Japanese Heart JournalOpen Access

Efficacy of Direct Injection of Ethanol into the Myocardium to Control Aconitine-induced Ventricular Tachycardia in Anesthetized Dogs.

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Why the study?

Does direct injection of ethanol into the myocardium restore sinus rhythm in anesthetized dogs with aconitine-induced ventricular tachycardia?

Population

30 anesthetized dogs with aconitine-induced ventricular tachycardia

Design

Preclinical

Authors

AKAkira KURITAJikei University School of MedicineHMHideki MitaniCedars-Sinai Medical CenterRKRitushi KATONational Defense Medical College

Discussion

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Implication

Ethanol myocardial injection merits further animal validation for VT; leaves open any clinical translation pending safety data.

Structured PICO

Does direct injection of ethanol into the myocardium restore sinus rhythm in anesthetized dogs with aconitine-induced ventricular tachycardia?

P
Population
30 anesthetized dogs with aconitine-induced ventricular tachycardia (17 epicardial induction, 13 endocardial induction)
I
Intervention
Direct injection of 96% ethanol into the myocardium (median 0.6 ml for epicardial, 2.0 ml for endocardial)
O
Outcome
Restoration of regular sinus rhythmsurrogate

Direct myocardial injection of ethanol can restore sinus rhythm in a canine model of aconitine-induced ventricular tachycardia, though with a risk of fatal ventricular fibrillation.

Cite This Study

KURITA et al. (1996) studied this question.

synapsesocial.com/papers/6a1bd031d54006be995f0a30https://doi.org/10.1536/ihj.37.611

Topics

Ventricular arrhythmias
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epicardial and subselective transcoronary chemical ablation of incessant ventricular tachycardia1993 · 12 citations
  2. 2Surgical ablation of ventricular tachycardia with sequential map-guided subendocardial resection: electrophysiologic assessment and long-term follow-up.1988 · 70 citations
  3. 3Determinants of Survival in Patients with Ventricular Tachyarrhythmias1983 · 509 citations
  4. 4Randomized Study of Implantable Defibrillator as First-Choice Therapy Versus Conventional Strategy in Postinfarct Sudden Death Survivors1995 · 241 citations
  5. 5Automatic Implantable Cardioverter Defibrillators and Survival of Patients with Left Ventricular Dysfunction and Malignant Ventricular Arrhythmias1988 · 337 citations