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June 2, 2026CureusOpen Access

NDM-Producing Klebsiella pneumoniae and Multidrug-Resistant Enterococcus faecium Bacteremia: A Report of Two Cases

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Authors

NDNikolaos Iason DavanellosPSPolyxeni StefaRGRafail Giannas

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Overview

Case report shows severe infections from multidrug-resistant bacteria, stressing the need for rapid diagnosis and tailored treatment.

Key Points

  • This report aims to highlight the complexities of managing severe bloodstream infections caused by multidrug-resistant pathogens.
  • Case reports of two patients with urinary-source bacteremia due to multidrug-resistant bacteria.
  • Treatment in first case included ceftazidime-avibactam, while second case had escalated antimicrobial therapy.
  • Focus on the role of microbiological diagnosis and infection prevention measures.
  • First patient improved clinically with ceftazidime-avibactam and was discharged from the hospital.
  • Second patient experienced clinical deterioration despite treatment and subsequently died.
  • Cases emphasize challenges in managing infections from highly resistant pathogens.

Cite This Study

Davanellos et al. (2026) studied this question.

synapsesocial.com/papers/6a1e738130b38c64201b68e6https://doi.org/10.7759/cureus.109960
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P-1197. NDM-5 and Siderophore Receptor Mutations Drive High Level Cefiderocol Resistance in Klebsiella pneumoniae: A Case Series2026
  2. 2INFECTIONS CAUSED BY NDM- AND NDM+KPC-PRODUCING ENTEROBACTERALES: EPIDEMIOLOGICAL PROFILE IN A UNIVERSITY HOSPITAL2026
  3. 3Cefiderocol Heteroresistance in NDM-Producing Enterobacterales: A Complex Polymicrobial Infection Successfully Salvaged With Ceftazidime-Avibactam Plus Aztreonam2026
  4. 4COMPLEX SKIN AND SOFT TISSUE INFECTION BY NEW DELHI METALLO-Β-LACTAMASE ‒ PRODUCING ENTEROBACTERALES2026
  5. 5P-1344. Clinical outcomes of patients with NDM-producing Enterobacterales bloodstream infections in a healthcare system in New York2026