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July 1, 1980Journal of Clinical InvestigationOpen Access

Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man.

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Why the study?

What are the plasma epinephrine thresholds for metabolic and hemodynamic actions and metabolic clearance rates in normal human subjects?

Population

6 normal human subjects

Design

Other

Follow-up

60 minutes per infusion

Authors

WCWilliam E. ClutterWashington University in St. LouisDBDennis M. BierUniversity of Arkansas at Little RockSSS D ShahCertis USA (United States)

Discussion

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Implication

Confirms epinephrine effects at physiologic levels in healthy subjects; leaves open extension to disease states or clinical decision-making.

Structured PICO

What are the plasma epinephrine thresholds for metabolic and hemodynamic actions and metabolic clearance rates in normal human subjects?

P
Population
6 normal human subjects
I
Intervention
60-min intravenous epinephrine infusions at nominal rates of 0.1, 0.5, 1.0, 2.5, and 5.0 microgram/min
O
Outcome
Plasma epinephrine thresholds for metabolic and hemodynamic actions and plasma epinephrine metabolic clearance ratessurrogate

Epinephrine thresholds for hemodynamic and metabolic actions lie within the physiologic range, and epinephrine accelerates its own metabolic clearance.

Cite This Study

Clutter et al. (1980) studied this question.

synapsesocial.com/papers/6a1e73df09554abc3868d48bhttps://doi.org/10.1172/jci109840
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Also Consider

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  3. 3Plasma Catecholamine Levels in the Coronary Sinus, Aorta and Femoral Vein of Subjects Undergoing Cardiac Catheterization at Rest and During Exercise.1976 · 25 citations
  4. 4Studies on the Mechanism of Epinephrine-induced Hyperglycemia in Man: Evidence for Participation of Pancreatic Glucagon Secretion1976 · 114 citations