Why the study?
Do elevated factor XIa and thrombin generation on admission predict recurrent cardiovascular events in patients with acute coronary syndrome?
Population
146 patients, comprising 104 with acute coronary syndrome (ACS) and 42 non-ACS patients.
Comparison
Measurement of plasma thrombin generation… vs Non-ACS patients and lower biomarker levels.
Design
Cohort
Follow-up
6 months
Authors
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May aid ACS risk stratification; hypothesis-generating for factor XIa-targeted trials.
Do elevated factor XIa and thrombin generation on admission predict recurrent cardiovascular events in patients with acute coronary syndrome?
Elevated factor XIa and thrombin generation on admission in ACS patients are associated with an increased risk of recurrent cardiovascular events.
Loeffen et al. (2016) studied this question.
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