Key result
Patients with a previous acute myocardial infarction exhibited significantly earlier, faster, and higher thrombin generation than those with stable chronic CAD (P<0.001).
Why the study?
Does a history of acute myocardial infarction result in persistently increased thrombin generation compared to chronic stable CAD?
Population
110 participants including 15 healthy controls, 35 patients with chronic stable CAD, and 60 patients 3-11…
Comparison
Prior acute myocardial infarction (AMI) vs Chronic stable CAD and healthy controls
Design
Cross-sectional
Follow-up
mean 6 months after initial diagnosis
Authors
Loading...
May indicate persistent hypercoagulability after AMI; hypothesis-generating for thrombin assays in chronic CAD risk stratification.
Cross-Sectional (n=110)
Does a history of acute myocardial infarction result in persistently increased thrombin generation compared to chronic stable CAD?
p-value: p=<0.001
Patients with a history of acute CAD exhibit a persistent hypercoagulable state with faster and higher thrombin generation compared to those with stable chronic CAD.
Orbe et al. (2008) conducted a cross-sectional in Coronary artery disease (n=110). Prior acute myocardial infarction (AMI) vs. Chronic stable CAD was evaluated on Thrombin generation (lag phase, velocity index, and peak thrombin) (p=<0.001). Patients with a previous acute myocardial infarction exhibited significantly earlier, faster, and higher thrombin generation than those with stable chronic CAD (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: