What does this research mean for the field?

Specific amino acid residues within the highly conserved alpha-1 and alpha-2 repeats, as well as a region similar to the Na+,K+ pump, are critical for ion binding and translocation in the cardiac sarcolemmal Na+-Ca2+ exchanger. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1996Journal of Biological ChemistryOpen Access

Mutation of Amino Acid Residues in the Putative Transmembrane Segments of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger

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Structured PICO

Population

Cardiac sarcolemmal Na+-Ca2+ exchanger model

Intervention

Site-directed mutagenesis of conserved regions and acidic or basic residues in putative transmembrane segments

Outcome

Na+-Ca2+ exchange activitysurrogate

The alpha-repeats and pump-like regions of the cardiac sarcolemmal Na+-Ca2+ exchanger are critical components for ion binding and translocation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Identifies NCX residues for functional studies; leaves open therapeutic targeting in human cardiac disease.

Cite This Study

Nicoll et al. (1996) studied this question.

synapsesocial.com/papers/6a1e802220458ccdef55f70a https://doi.org/10.1074/jbc.271.23.13385

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Mutation of Amino Acid Residues in the Putative Transmembrane Segments of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger

Structured PICO

Discussion

Implication

Cite This Study

Mutation of Amino Acid Residues in the Putative Transmembrane Segments of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider