January 1, 2001Journal of Biological ChemistryOpen Access

Helix Packing of Functionally Important Regions of the Cardiac Na+-Ca2+ Exchanger

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Population

HEK293 cells expressing mutant cardiac Na+-Ca2+ exchanger proteins

Design

Preclinical

Authors

ZQZhiyong QiuJiangsu University of Science and Technology DNDebora A. NicollUniversity of California, Los Angeles KPKenneth D. PhilipsonElectrophysiology

Discussion

Member takes

Implication

Supports NCX transmembrane packing model; leaves open whether alpha-repeat proximity guides human NCX inhibitor design.

Structured PICO

Population

HEK293 cells expressing mutant cardiac Na+-Ca2+ exchanger proteins

Intervention

Cysteine mutagenesis and oxidative cross-linking

Outcome

Disulfide bond formation between introduced cysteines analyzed by gel mobility shiftssurrogate

This initial packing model of the cardiac Na+-Ca2+ exchanger demonstrates that the functionally important alpha 1 and alpha 2 repeats are located close to each other.

Cite This Study

Qiu et al. (2001) studied this question.

synapsesocial.com/papers/6a7997a8a51ded8e7b3244ed https://doi.org/10.1074/jbc.m005571200

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Helix Packing of Functionally Important Regions of the Cardiac Na+-Ca2+ Exchanger

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Helix Packing of Functionally Important Regions of the Cardiac Na+-Ca2+ Exchanger

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider