August 1, 1978Canadian Journal of Physiology and Pharmacology

Muscarinic inhibition of endogenous myocardial catecholamine liberation in the dog

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Population

Anesthetized dogs

Comparison

Vagal electrical stimulation superposed on… vs Basal sympathetic tone and sympathetic…

Design

Preclinical

Authors

MLMichel LavalléeBoehringer Ingelheim (Germany)JCJacques de ChamplainGeneral / Preventive / Lipids RNRéginald NadeauRoche (Switzerland)

Discussion

Member takes

Implication

Vagal-sympathetic interaction in canine hearts merits human investigation; Level 5 data leaves clinical translation open.

Structured PICO

Population

Anesthetized dogs

Intervention

Vagal electrical stimulation (1, 2, 4, 8, 16 Hz) superposed on sympathetic stimulation (right cardioaccelerator nerves at 10 Hz), atropine (2 μg/kg), and methacholine (3 μg/kg per minute) infusion

Comparator

Basal sympathetic tone and sympathetic stimulation alone

Outcome

Release of endogenous catecholamine (CA) into the coronary sinussurrogate

Vagal stimulation functionally inhibits sympathetic catecholamine liberation in the canine heart, likely mediated by presynaptic muscarinic receptors.

Cite This Study

Lavallée et al. (1978) studied this question.

synapsesocial.com/papers/6a1e86fc40bc8a3dd769052a https://doi.org/10.1139/y78-102

View Full Paper

Ask AI

Bookmark

Muscarinic inhibition of endogenous myocardial catecholamine liberation in the dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Muscarinic inhibition of endogenous myocardial catecholamine liberation in the dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider