What does this research mean for the field?

A combined profile of reduced eosinophil percentage and elevated high-sensitivity C-reactive protein predicts a significantly higher risk of in-hospital major adverse cardiac events in STEMI patients undergoing primary percutaneous coronary intervention. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 22, 2020Journal of Clinical Laboratory AnalysisOpen Access

Combination of eosinophil percentage and high‐sensitivity C‐reactive protein predicts in‐hospital major adverse cardiac events in ST‐elevation myocardial infarction patients undergoing primary percutaneous coronary intervention

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Why the study?

Both eosinophils and hs-CRP play a major role in the acute inflammatory response of myocardial infarction, but their combined prognostic value for in-hospital adverse events in STEMI patients undergoing primary PCI required evaluation.

Does the combination of reduced eosinophil percentage and elevated hs-CRP predict in-hospital MACEs in STEMI patients undergoing primary PCI?

Structured PICO

Does the combination of reduced eosinophil percentage and elevated hs-CRP predict in-hospital MACEs in STEMI patients undergoing primary PCI?

Population

518 STEMI patients undergoing primary percutaneous coronary intervention

Intervention

Combination of reduced eosinophil percentage (≤0.3%) and elevated hs-CRP (>11.8 mg/L)

Comparator

Patients with neither or only one of the risk factors (EOS% ≤0.3% or hs-CRP >11.8 mg/L)

Outcome

In-hospital major adverse cardiac events (MACEs), defined as cardiac rupture, cardiac arrest, malignant arrhythmia, and cardiac deathcomposite

Combined reduced eosinophil percentage and elevated hs-CRP can identify STEMI patients at high risk for in-hospital MACEs following primary PCI.

Discussion

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Implication

May flag high-risk STEMI patients post-PCI; leaves open incremental value over standard models.

Cite This Study

Ye et al. (2020) studied this question.

synapsesocial.com/papers/6a1e894d20458ccdef5604f8 https://doi.org/10.1002/jcla.23367

Topics

STEMI management Percutaneous coronary intervention

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Combination of eosinophil percentage and high‐sensitivity C‐reactive protein predicts in‐hospital major adverse cardiac events in ST‐elevation myocardial infarction patients undergoing primary percutaneous coronary intervention

Structured PICO

Discussion

Implication

Cite This Study

Topics

Combination of eosinophil percentage and high‐sensitivity C‐reactive protein predicts in‐hospital major adverse cardiac events in ST‐elevation myocardial infarction patients undergoing primary percutaneous coronary intervention

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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