Key result
Low eosinophil percentage (≤0.60%) on admission was independently associated with a significantly higher rate of inhospital major adverse cardiac events compared to higher percentages (32.8% vs. 11.3%) in STEMI patients.
Why the study?
Eosinophils have proinflammatory and prothrombotic properties, prompting investigation into the association between eosinophil percentage and major adverse cardiac events in STEMI patients.
Does low eosinophil percentage on admission predict inhospital MACE in patients with STEMI undergoing primary PCI?
Observational (n=1,909)
No
Does low eosinophil percentage on admission predict inhospital MACE in patients with STEMI undergoing primary PCI?
Odds Ratio: 0.441 (95% CI 0.301–0.646)
Absolute Event Rate: 32.8% vs 11.3%
p-value: p=0.001
Low eosinophil percentage (<0.60%) on admission is an independent predictor of inhospital major adverse cardiac events in patients with STEMI undergoing primary PCI.
Low eosinophil percentage was associated with higher inhospital MACE in STEMI; hypothesis-generating and requires prospective validation before clinical adoption.
Background In addition to proinflammatory properties, eosinophils can stimulate platelet activation and enhance prothrombotic pathways. In this study, we aimed to investigate the association between the eosinophil percentage (EOS%) and major adverse cardiac events (MACE) in patients with ST-segment elevation myocardial infarction (STEMI). Methods This study enrolled a total of 1,909 patients who were diagnosed with STEMI. Ventricular arrhythmia, reinfarction, the need for cardiopulmonary resuscitation, target vessel revascularization, congestive heart failure, and cardiovascular mortality during index hospitalization were defined as MACE. Results Three hundred and eighty patients (19.7%) reached the combined endpoint with MACE. The rates of inhospital mortality and MACE were significantly higher in low EOS% group as compared to high EOS% group (4% vs. 1.1%, p < 0.01 and 32.8% vs. 11.3%, p < 0.01, respectively). On multivariate logistic regression analyses, EOS% (OR = 0.44, p < 0.01) was found to be one of the independent predictors of MACE. The EOS% lower than 0.60 on admission predicted inhospital MACE with a sensitivity of 68% and a specificity of 72% (AUC: 0.684, p < 0.01). Conclusions Low EOS% on admission may be associated with high inhospital MACE in STEMI patients. EOS% may be used as a novel biomarker for risk stratification of these patients.
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Güner et al. (2019) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=1,909). Low eosinophil percentage (≤0.60%) vs. High eosinophil percentage (>0.60%) was evaluated on Inhospital major adverse cardiac events (MACE) (OR 0.441, 95% CI 0.301-0.646, p=0.001). Low eosinophil percentage (≤0.60%) on admission was independently associated with a significantly higher rate of inhospital major adverse cardiac events compared to higher percentages (32.8% vs. 11.3%) in STEMI patients.
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