Key result
Higher admission eosinophil-to-monocyte ratio is linked to ~82% lower long-term mortality after STEMI PCI.
Why the study?
The relationship between eosinophil-to-monocyte ratio on admission and short-term and long-term all-cause mortality in STEMI patients undergoing primary PCI was not established.
Does eosinophil-to-monocyte ratio on admission predict 1-month and long-term all-cause mortality in STEMI patients undergoing primary PCI?
Cohort (n=426)
Does eosinophil-to-monocyte ratio on admission predict 1-month and long-term all-cause mortality in STEMI patients undergoing primary PCI?
Hazard Ratio: 0.176 (95% CI 0.045–0.694)
p-value: p=0.013
Lower eosinophil-to-monocyte ratio on admission is independently associated with increased 1-month and long-term all-cause mortality in STEMI patients undergoing primary PCI, serving as a potential risk stratification tool.
May support EMR for STEMI risk stratification; hypothesis-generating and requires prospective validation.
BACKGROUND: To determine the relationship between eosinophil-to-monocyte ratio (EMR) on admission and one-month and long-term all-cause mortality in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (P-PCI). METHODS: A total of 426 consecutive STEMI patients treated with P-PCI were enrolled and categorized in terms of tertiles of EMR on admission between September 2015 and October 2017. Final follow-up for long-term outcomes was January 2017. RESULTS: As EMR decreased, all-cause mortality at 1 month (mean, 29.5±3.5 days) and at mean 14.1±7.8 months follow-up increased (P=0.012, P=0.003, respectively). Kaplan-Meier survival curve analysis showed EMR was associated with 1-month and long-term all-cause mortality (P=0.048, P=0.015, respectively). In multivariate Cox proportional hazards analysis, EMR was independently associated with one-month and long-term mortality (hazard ratio =0.097; 95% CI, 0.010-0.899; P=0.04; hazard ration =0.176; 95% CI, 0.045-0.694; P=0.013). The area under the curve of EMR for the prediction of 1-month and long-term total mortality in receiver operating characteristic analysis was 0.789 (95% CI, 0.658-0.921; P=0.003) and 0.752 (95% CI, 0.619-0.884; P=0.001), respectively. CONCLUSIONS: EMR on admission was independently correlated with 1-month and long-term all-cause mortality in STEMI patients undergoing P-PCI, suggesting EMR as a potential simple, useful, and inexpensive index for risk stratification of STEMI patients.
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Deng et al. (2018) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=426). Eosinophil-to-monocyte ratio (EMR) on admission was evaluated on Long-term all-cause mortality (HR 0.176, 95% CI 0.045-0.694, p=0.013). Eosinophil-to-monocyte ratio on admission was independently associated with long-term all-cause mortality in STEMI patients undergoing primary PCI (HR 0.176; 95% CI 0.045-0.694; P=0.013).
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