Key result
Low lymphocyte-to-monocyte ratio linked to ~8-fold higher mortality in STEMI patients undergoing primary PCI.
Why the study?
The relationship between lymphocyte-to-monocyte ratio 48 hours after admission and mortality in STEMI patients treated with primary PCI was investigated.
Does a low lymphocyte-to-monocyte ratio (LMR) 48 hours after admission predict 30-day and long-term mortality in patients with STEMI undergoing primary PCI?
Population
318 consecutive STEMI patients treated with primary PCI
Comparison
Low LMR (T3 <1.67 and T2 1.67-2.46) vs high LMR (T1 >2.46) at 48 hours
Design
Cohort study
Follow-up
30-day and long-term
Authors
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Post-PCI LMR may aid mortality risk stratification in STEMI; leaves open whether it improves existing models or alters management.
Cohort (n=318)
Does a low lymphocyte-to-monocyte ratio (LMR) 48 hours after admission predict 30-day and long-term mortality in patients with STEMI undergoing primary PCI?
Hazard Ratio: 8.093 (95% CI 1.006–65.074)
p-value: p=.049
A low lymphocyte-to-monocyte ratio at 48 hours post-admission is an independent prognostic marker for increased 30-day and long-term mortality in STEMI patients treated with primary PCI.
Kırış et al. (2017) conducted a cohort in ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) (n=318). Low lymphocyte-to-monocyte ratio (Tertile 3: <1.67) at 48 hours vs. High lymphocyte-to-monocyte ratio (Tertile 1: >2.46) was evaluated on 30-day all-cause mortality (HR 8.093, 95% CI 1.006-65.074, p=.049). A low lymphocyte-to-monocyte ratio (<1.67) at 48 hours was associated with increased 30-day all-cause mortality in STEMI patients undergoing primary PCI (HR 8.093; 1.006-65.074; P=.049).
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