Why the study?
Does insulin treatment reduce elevated 1,2-diacylglycerol content in the myocardium of streptozocin-induced diabetic rats?
Does insulin treatment reduce elevated 1,2-diacylglycerol content in the myocardium of streptozocin-induced diabetic rats?
In a rat model of diabetic cardiomyopathy, elevated myocardial 1,2-diacylglycerol levels are not reversed by insulin therapy, suggesting a sustained mechanism for protein kinase C activation.
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Persistent myocardial DAG elevation despite insulin in diabetic rats; hypothesis-generating for PKC-targeted therapies in diabetic cardiomyopathy.
Okumura et al. (1988) studied this question.
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