Why the study?
Does insulin treatment normalize 1,2-DAG content and fatty acid composition in the thoracic aorta of streptozocin-induced diabetic rats?
Does insulin treatment normalize 1,2-DAG content and fatty acid composition in the thoracic aorta of streptozocin-induced diabetic rats?
Decreased 1,2-DAG content in the thoracic aorta of diabetic rats suggests a defect in its production may contribute to abnormal vascular smooth muscle responsiveness in diabetes, which can be mitigated by insulin.
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Suggests 1,2-DAG defects may underlie diabetic vasculopathy; hypothesis-generating and leaves open human translation.
Okumura et al. (1991) studied this question.
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