Key result
Glomeruli from streptozocin-induced diabetic rats exhibited twofold higher PGE2 production and phospholipase A2 activity compared to normal rats, which was prevented by insulin treatment.
Enhanced phospholipase A2 activity mediates increased arachidonate availability and prostaglandin synthesis in diabetic rat glomeruli, which can be prevented by insulin treatment.
No takes yet. Share an insight, caveat, or question.
These rat data do not support clinical changes; they leave open PGE2's role in human diabetic nephropathy.
Craven et al. (1988) studied Diabetes. Streptozocin-induced diabetes vs. Normal rats was evaluated on Prostaglandin E2 (PGE2) production and phospholipase A2 activity. Glomeruli from streptozocin-induced diabetic rats exhibited twofold higher PGE2 production and phospholipase A2 activity compared to normal rats, which was prevented by insulin treatment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: