Why the study?
Does valsartan alter renal production and conversion of prostaglandins E2 to F2α in conscious diabetic rats?
Population
Conscious diabetic rats
Comparison
Valsartan (angiotensin type 1 receptor blocker) vs Control (untreated diabetic rats)
Design
Preclinical
Follow-up
6 weeks
Authors
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May identify AT1R-PGE2 targets in diabetic nephropathy; leaves open whether modulation alters progression in patients.
Does valsartan alter renal production and conversion of prostaglandins E2 to F2α in conscious diabetic rats?
In diabetic rats, AT1R blockade with valsartan reduces PGE2 generation and increases its conversion to PGF2α, suggesting AT1R mediates aberrant prostaglandin metabolism in diabetes.
Abadir et al. (2015) studied this question.
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