September 1, 1997AJP Regulatory Integrative and Comparative Physiology
The subtype 2 angiotensin receptor regulates renal prostaglandin F2 alpha formation in conscious rats
Population
Conscious rats
Comparison
5 days of sodium depletion combined with… vs 5 days of sodium depletion alone
Design
Preclinical
Follow-up
5 days
Authors
Discussion
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Member takes
Implication
Caution against clinical extrapolation; extends AT2-mediated prostaglandin mechanisms in animal sodium depletion models.
Structured PICO
P
Population
Conscious rats
I
Intervention
5 days of sodium depletion combined with intravenous infusion of the AT1 receptor blocker losartan or the AT2 receptor blocker PD-123319
C
Comparator
5 days of sodium depletion alone
O
Outcome
Changes in renal interstitial fluid PGE2 and PGF2 alpha, and PGF2 alpha-to-PGE2 ratiosurrogate
The study demonstrates that activation of the renin-angiotensin system during sodium depletion physiologically increases renal conversion of PGE2 to PGF2 alpha via the angiotensin AT2 receptor.
Cite This Study
Siragy et al. (1997) studied this question.