Why the study?
Does the absence of the AT2 receptor alter prostaglandin metabolism and blood pressure regulation in mice?
Population
Mice with targeted deletion of the angiotensin subtype-2 receptor gene and wild-type control mice
Comparison
Indomethacin treatment for 14 days; dietary… vs Wild-type (WT) control mice
Design
Preclinical
Follow-up
14 days (for indomethacin treatment)
Authors
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Highlights compensatory prostanoid effects in AT2 deficiency; hypothesis-generating for human hypertension mechanisms and therapies.
Does the absence of the AT2 receptor alter prostaglandin metabolism and blood pressure regulation in mice?
In mice lacking the AT2 receptor, increased vasodilator prostanoids protect against the development of hypertension.
Siragy et al. (1999) studied this question.
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