What question did this study set out to answer?

The aim is to examine the levels of 1,2-diacylglycerol and ceramide in tissues of insulin-resistant rats.

October 1, 1990Journal of Biological ChemistryOpen Access

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

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Authors

JTJ. TurinskySkidmore College DODavid O’SullivanMalaghan Institute of Medical Research BBB. P. BaylyAlbany Medical Center Hospital

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Implication

Randomized trial investigates 1,2-diacylglycerol and ceramide levels in insulin-resistant rats, suggesting potential contributions to insulin resistance.

Key Points

The aim is to examine the levels of 1,2-diacylglycerol and ceramide in tissues of insulin-resistant rats.
Studied 11-12-week-old genetically obese Zucker rats and lean controls.
Measured levels of 1,2-diacylglycerol and ceramide in liver, calf muscles, soleus muscle, and plantaris muscle.
Analyzed changes in these levels after nerve supply interruption to hindlimb muscles.
1,2-diacylglycerol increased by 82% in liver and 136% in calf muscles of obese rats.
Ceramide levels also increased significantly in the same tissues, indicating a relationship with insulin resistance.
Denervated soleus muscles showed a sustained increase in 1,2-diacylglycerol concentration over 15 days.

Cite This Study

Turinsky et al. (1990) studied this question.

synapsesocial.com/papers/6a06cac22edded7c7b841534 https://doi.org/10.1016/s0021-9258(17)44844-7

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Implication

Randomized trial investigates 1,2-diacylglycerol and ceramide levels in insulin-resistant rats, suggesting potential contributions to insulin resistance.

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

Discussion

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Implication

Key Points

Cite This Study

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

Discussion

Member takes

Implication

Key Points

Cite This Study

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