Why the study?
Does peripheral insulin treatment prevent diabetes-induced alterations in myocardial lipid molecular species in a streptozotocin-induced diabetic rat model?
Population
Rat model of diabetes induced by streptozotocin treatment
Comparison
Peripheral insulin treatment vs Diabetic rats without insulin treatment
Design
Preclinical
Authors
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Insulin leaves triacylglycerol remodeling uncorrected in diabetic rat myocardium; hypothesis-generating for adjunctive therapies beyond glycemic control.
Does peripheral insulin treatment prevent diabetes-induced alterations in myocardial lipid molecular species in a streptozotocin-induced diabetic rat model?
Peripheral insulin therapy alone may not be sufficient to correct all metabolic alterations, specifically triacylglycerol remodeling, present in diabetic myocardium.
Han et al. (2000) studied this question.
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