Why the study?
Is overnight rostral fluid shift associated with obstructive sleep apnea severity in hypertensive subjects, and is its magnitude greater in drug-resistant hypertension?
Population
40 hypertensive subjects undergoing overnight polysomnography, including 25 with drug-resistant hypertension…
Comparison
Measurement of overnight rostral fluid shift. vs Controlled hypertensive subjects (n=15).
Design
Cross-sectional
Follow-up
overnight
Authors
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Fluid dynamics warrant evaluation in resistant hypertension with OSA; extends mechanistic observations but leaves causal inference and practice change open.
Is overnight rostral fluid shift associated with obstructive sleep apnea severity in hypertensive subjects, and is its magnitude greater in drug-resistant hypertension?
Overnight rostral fluid displacement is strongly associated with the severity of obstructive sleep apnea in hypertensive patients, with a significantly greater magnitude observed in those with drug-resistant hypertension.
Friedman et al. (2010) studied this question.
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