Why the study?
Does graded lower body positive pressure cause greater rostral fluid shift and upper airway narrowing in patients with drug-resistant hypertension compared to controlled hypertension?
Population
40 patients, comprising 25 with drug-resistant hypertension and 15 with controlled hypertension.
Comparison
Graded lower body positive pressure vs Controlled hypertension patients
Design
Cross-sectional
Authors
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Supports mechanistic link between fluid shifts and OSA in resistant hypertension; hypothesis-generating, requires prospective trials before practice implications.
Does graded lower body positive pressure cause greater rostral fluid shift and upper airway narrowing in patients with drug-resistant hypertension compared to controlled hypertension?
Exaggerated rostral fluid displacement from the legs in drug-resistant hypertension narrows the upper airway, providing a mechanistic link between drug-resistant hypertension and obstructive sleep apnea.
Friedman et al. (2012) studied this question.
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