What does this research mean for the field?

The antiplatelet and antithrombotic effects of statins and fibrates are mediated by the activation of PPARalpha and PPARgamma and their subsequent association with PKCalpha in platelets. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

January 16, 2009Arteriosclerosis Thrombosis and Vascular Biology

Antiplatelet Actions of Statins and Fibrates Are Mediated by PPARs

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Why the study?

Do statins and fibrates inhibit platelet function via PPAR-dependent mechanisms?

Structured PICO

Do statins and fibrates inhibit platelet function via PPAR-dependent mechanisms?

Population

Human platelets in vitro, participants in a small-scale human study, and wild-type vs PPARalpha-/- mice

Intervention

Statins (simvastatin, fluvastatin) and fibrates (fenofibrate)

Comparator

PPAR antagonists (GW9662, GW6471), PPARalpha-/- mice, or baseline

Outcome

Platelet activation, aggregation, and bleeding timesurrogate

Statins and fibrates exert antiplatelet effects through PPAR-dependent mechanisms involving association with PKCalpha, providing a unifying explanation for their pleiotropic cardiovascular benefits.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for PPAR-PKCalpha antiplatelet mechanisms; leaves open clinical translation and requires human trials.

Cite This Study

Ali et al. (2009) studied this question.

synapsesocial.com/papers/6a1e8f4cd258f1f64202a7e6 https://doi.org/10.1161/atvbaha.108.183160

Topics

Statin therapy Dual antiplatelet therapy

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Antiplatelet Actions of Statins and Fibrates Are Mediated by PPARs

Structured PICO

Discussion

Implication

Cite This Study

Topics

Antiplatelet Actions of Statins and Fibrates Are Mediated by PPARs

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider