Why the study?
How does stellate ganglion stimulation affect coronary blood flow during blockade with different beta-adrenoceptor antagonists?
How does stellate ganglion stimulation affect coronary blood flow during blockade with different beta-adrenoceptor antagonists?
Practolol differs from other beta-blockers by allowing coronary vasodilatation rather than vasoconstriction during stellate ganglion stimulation.
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Practolol permits coronary vasodilatation during stellate stimulation unlike other beta-blockers; leaves open differential effects in humans.
The β-adrenoceptor antagonists LB46, oxprenolol, K01366, propranolol, and practolol all decrease the myocardial demand for oxygen and increase efficiency; with the exception of practolol, they reduce coronary blood flow. Stellate ganglion stimulation causes coronary vasoconstriction after β-adrenoceptor blockade has been established with propranolol, LB46, oxprenolol, or K01366; in the presence of practolol it causes coronary vasodilatation.
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Nayler et al. (1973) studied this question.
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