What does this research mean for the field?

Long-term treatment with the traditional Chinese medication Qiliqiangxin protects against cardiac remodeling and dysfunction in hypertension by increasing PPARs and PGC-1α expression. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2017International Journal of Medical SciencesOpen Access

Traditional Chinese Medication Qiliqiangxin Protects Against Cardiac Remodeling and Dysfunction in Spontaneously Hypertensive Rats

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Why the study?

Does Qiliqiangxin improve cardiac remodeling and dysfunction in thirteen-week-old spontaneously hypertensive rats?

Population

Thirteen-week-old spontaneously hypertensive rats (SHRs)

Comparison

Qiliqiangxin daily intragastric administration… vs Saline daily intragastric administration for one…

Design

Preclinical

Follow-up

1 year

Authors

HWHui WangTianjin University of Traditional Chinese Medicine XZXiaomin ZhangHebei Medical University PYPujiao YuSecond Military Medical University

Discussion

Member takes

Implication

Hypothesis-generating for QLQX in hypertensive remodeling; leaves open clinical translation pending human trials.

Structured PICO

Does Qiliqiangxin improve cardiac remodeling and dysfunction in thirteen-week-old spontaneously hypertensive rats?

Population

Thirteen-week-old spontaneously hypertensive rats (SHRs)

Intervention

Qiliqiangxin (QLQX) daily intragastric administration for one year

Comparator

Saline daily intragastric administration for one year

Outcome

Cardiac function (measured by echocardiography), mitochondria ultrastructure (measured by electron microscopy), and cardiac fibrosis (measured by Masson's trichrome staining)surrogate

Long-term treatment with Qiliqiangxin protects against cardiac remodeling and dysfunction in a hypertensive rat model, potentially via upregulation of PPARs and PGC-1α.

Cite This Study

Wang et al. (2017) studied this question.

synapsesocial.com/papers/6a1e9b0c8fda1017a847df5b https://doi.org/10.7150/ijms.18142

Topics

Hypertension management Echocardiography

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Traditional Chinese Medication Qiliqiangxin Protects Against Cardiac Remodeling and Dysfunction in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Traditional Chinese Medication Qiliqiangxin Protects Against Cardiac Remodeling and Dysfunction in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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