Key result
Spironolactone and triamterene exerted opposing effects on PAI-1 antigen (P=0.006), with spironolactone decreasing PAI-1 in hypertensive subjects and triamterene increasing it in normotensives.
Why the study?
Does spironolactone improve fibrinolytic balance compared to triamterene in subjects pretreated with hydrochlorothiazide?
Does spironolactone improve fibrinolytic balance compared to triamterene in subjects pretreated with hydrochlorothiazide?
p-value: p=0.006
Spironolactone improves fibrinolytic balance by decreasing PAI-1 antigen in hypertensive subjects through a mineralocorticoid receptor-dependent, potassium-independent mechanism.
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Spironolactone may be preferred over triamterene for fibrinolytic balance on HCTZ; confirms MR-dependent PAI-1 effects in hypertension.
Ma et al. (2005) studied Hypertension and Normotension (n=38). Spironolactone vs. Triamterene (50 mg per day) was evaluated on PAI-1 antigen concentrations (p=0.006). Spironolactone and triamterene exerted opposing effects on PAI-1 antigen (P=0.006), with spironolactone decreasing PAI-1 in hypertensive subjects and triamterene increasing it in normotensives.
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