Why the study?
Does spironolactone prevent Ang II-induced structural and mechanical changes in resistance arteries in male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats
Comparison
Angiotensin II with or without spironolactone or… vs Control group
Design
Preclinical
Follow-up
2 weeks
Authors
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Spironolactone may attenuate Ang II vascular effects beyond BP reduction in rats; leaves open translation to human resistance artery remodeling.
Does spironolactone prevent Ang II-induced structural and mechanical changes in resistance arteries in male Sprague-Dawley rats?
Spironolactone partially prevents Ang II-induced vascular structural and mechanical alterations in rats independently of blood pressure reduction, suggesting aldosterone mediates some Ang II effects on resistance arteries.
Neves et al. (2003) studied this question.
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