Why the study?
Does spironolactone improve cardiovascular and renal dysfunction in a 2K1C rat model of renovascular hypertension?
Population
2 kidney-1 clip (2K1C) rat model of renovascular hypertension
Comparison
Spironolactone 200mg/kg/day for 7 days vs 2K1C rats not treated with spironolactone
Design
Preclinical
Follow-up
7 days
Authors
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Highlights aldosterone's role in sympathetic overactivity in experimental renovascular hypertension; leaves open human translation.
Does spironolactone improve cardiovascular and renal dysfunction in a 2K1C rat model of renovascular hypertension?
Spironolactone reduces blood pressure and normalizes renal sympathetic nerve activity in a rat model of renovascular hypertension, highlighting the role of aldosterone in autonomic and renal dysfunction.
Lincevicius et al. (2015) studied this question.
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