Key result
Spironolactone prevents a ~6-fold increase in aortic renin activity in aldosterone-induced hypertensive rats.
Why the study?
Does spironolactone prevent aldosterone-induced hypertension and changes in arterial renin activity in uninephrectomized rats?
Population
Uninephrectomized rats (normotensive and hypertensive models)
Comparison
D-aldosterone and sodium chloride with the… vs Uninephrectomized rats treated with…
Design
Preclinical
Follow-up
3-6 weeks
Authors
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Supports local vascular renin in rat hypertension models; hypothesis-generating for mineralocorticoid effects on human arteries.
Does spironolactone prevent aldosterone-induced hypertension and changes in arterial renin activity in uninephrectomized rats?
Spironolactone prevents aldosterone-induced hypertension and normalizes local aortic renin activity in rats, supporting the hypothesis that local vascular renin contributes to blood pressure regulation.
J Rosenthal (1976) studied Hypertension. D-aldosterone and sodium chloride with or without spironolactone vs. Control rats was evaluated on Total aortic renin activity and blood pressure. Aldosterone-induced hypertension in rats was associated with up to a sixfold increase in total aortic renin activity, an effect prevented by spironolactone.
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