Population
Recombinant rat neuronal cNOS and bovine endothelial cNOS expressed in E. coli, and iNOS from rat aortic…
Design
Preclinical
Authors
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May enable selective cNOS inhibition; hypothesis-generating and leaves open in vivo cardiovascular translation.
The identification of a unique 45-amino acid autoinhibitory insert in cNOS defines its calcium-dependent regulation and provides a novel target for NOS modulators.
Salerno et al. (1997) studied this question.
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