Key result
The pre-procedural electrical risk score strongly predicted 1-year all-cause mortality (OR 3.73; 95% CI 1.44-9.66; P<0.05) in elderly patients undergoing transcatheter aortic valve replacement.
Why the study?
Does the pre-procedural electrical risk score (ERS) predict 1-year mortality in elderly patients undergoing TAVR?
Cohort (n=40)
Does the pre-procedural electrical risk score (ERS) predict 1-year mortality in elderly patients undergoing TAVR?
Odds Ratio: 3.73 (95% CI 1.44–9.66)
p-value: p=<0.05
A simple 12-lead ECG-derived electrical risk score strongly predicts 1-year all-cause and cardiovascular mortality in elderly patients undergoing TAVR.
Objectives: To evaluate the predicative power of the electrical risk score (ERS), a noninvasive and inexpensive test obtained by means of a standard 12-lead electrocardiogram (ECG), in a cohort of elderly patients who had undergone transcatheter aortic valve replacement (TAVR). Methods: Survivors and non-survivors after TAVR at 1-year follow-up were compared in respect to the pre-procedural ERS as well as a number of other clinical and instrumental variables. ERS is composed of seven simple ECG markers: heart rate (>75 bpm); QRS duration (>110 ms); left ventricular hypertrophy (Sokolow–Lyon criteria); delayed QRS transition zone (≥ V4); frontal QRS-T angle (>90°); long QT Bazett (>450 ms for men and >460 in women) or JT Bazett (330 ms for men and >340 ms for women); and long Tpeak to Tend interval (T p-e ) (>89 ms). The trial was registered in ClinicalTrials.gov as NCT03145376. Results: A total of 40 patients were evaluated. During the follow-up, the all-cause mortality rate was 25% (ten patients) with 15% of cardiovascular death (six patients). The ERS was the strongest predictor of all-cause (odds ratio 3.73, 95% CI: 1.44–9.66, P <0.05) or cardiovascular (odds ratio 3.95, 95% CI: 1.09–14.27, P <0.05) mortality. Receiver operating characteristic curves showed that ERS had the widest significant sensitivity-specificity area under the curve (AUC) predicting all-cause (AUC: 0.855, P <0.05) or cardiovascular mortality (AUC: 0.908, P <0.05). Conclusion: ERS seems to be a useful noninvasive tool able to stratify the risk of mortality in 1-year follow-up of TAVR patients. These findings, however, require larger trials to be confirmed.
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Piccirillo et al. (2018) conducted a cohort in Aortic stenosis (n=40). Electrical risk score (ERS) was evaluated on All-cause mortality (OR 3.73, 95% CI 1.44-9.66, p=<0.05). The pre-procedural electrical risk score strongly predicted 1-year all-cause mortality (OR 3.73; 95% CI 1.44-9.66; P<0.05) in elderly patients undergoing transcatheter aortic valve replacement.
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