Key result
Proliferating bovine aortic endothelial cells produced about threefold more superoxide anion than postconfluent cells, which inactivated nitric oxide and reduced its bioactivity.
Population
Bovine aortic endothelial cells (BAEC) and RFL-6 reporter cells
Comparison
Cell proliferation and stimulation with calcium… vs Postconfluent/growth-arrested cells
Design
Preclinical
Authors
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Should not yet alter clinical practice; hypothesis-generating for superoxide-mediated NO inactivation in proliferating endothelium.
In bovine aortic endothelial cells, superoxide anion production is increased during proliferation and acts as a major determinant of nitric oxide breakdown.
Arnal et al. (1996) studied this question. Cell proliferation vs. Postconfluent (growth-arrested) cells was evaluated on Superoxide anion production and NO bioactivity. Proliferating bovine aortic endothelial cells produced about threefold more superoxide anion than postconfluent cells, which inactivated nitric oxide and reduced its bioactivity.
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