Key result
Exogenous nitric oxide inhibited endothelial cell proliferation in a dose-dependent manner, whereas endogenous levels of NO were inadequate to inhibit proliferation.
Relatively large concentrations of exogenous nitric oxide inhibit endothelial cell proliferation, while endogenous levels are inadequate to do so.
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Should not yet change NO donor use in patients; hypothesis-generating for dose-dependent endothelial effects in humans.
Gooch et al. (1997) studied this question. Exogenous and endogenous nitric oxide was evaluated on Endothelial cell proliferation. Exogenous nitric oxide inhibited endothelial cell proliferation in a dose-dependent manner, whereas endogenous levels of NO were inadequate to inhibit proliferation.
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