Key result
Cell proliferation in cultured aortic bovine endothelial cells was associated with three- and sixfold increases in NO synthase protein and mRNA, respectively, compared with growth-arrested cells.
Effect estimate: three- and sixfold increases
Endothelial cell NO synthase expression and activity are markedly increased during cell proliferation compared to quiescent states.
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May not guide endothelial therapies; leaves open translation from bovine cell culture findings.
Arnal et al. (1994) studied this question. Cell proliferation vs. Growth-arrested cells was evaluated on NO synthase protein and mRNA expression (three- and sixfold increases). Cell proliferation in cultured aortic bovine endothelial cells was associated with three- and sixfold increases in NO synthase protein and mRNA, respectively, compared with growth-arrested cells.
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