Key result
Cell proliferation in cultured aortic bovine endothelial cells was associated with three- and sixfold increases in NO synthase protein and mRNA, respectively, compared with growth-arrested cells.
Population
Cultured aortic bovine endothelial cells
Comparison
Cell proliferation (growing cells) vs Growth-arrested (quiescent) cells
Design
Preclinical
Authors
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May not guide endothelial therapies; leaves open translation from bovine cell culture findings.
Effect estimate: three- and sixfold increases
Endothelial cell NO synthase expression and activity are markedly increased during cell proliferation compared to quiescent states.
Arnal et al. (1994) studied this question. Cell proliferation vs. Growth-arrested cells was evaluated on NO synthase protein and mRNA expression (three- and sixfold increases). Cell proliferation in cultured aortic bovine endothelial cells was associated with three- and sixfold increases in NO synthase protein and mRNA, respectively, compared with growth-arrested cells.
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