Key result
Unilateral carotid artery occlusion in mice caused an immediate 26% reduction in left temporal cerebrocortical blood flow that recovered within 30 seconds, independent of eNOS.
Pial collaterals attenuate ischemia ipsilateral to carotid artery occlusion at the expense of frontoparietal blood supply, a process independent of eNOS.
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Rapid collateral flow recovery after carotid occlusion occurs independently of eNOS in mice; leaves open human translation.
Polycarpou et al. (2016) studied Carotid artery occlusion. Unilateral (left) carotid artery occlusion vs. Preocclusion baseline / wild-type controls was evaluated on Cerebrocortical blood flow (CoBF) changes. Unilateral carotid artery occlusion in mice caused an immediate 26% reduction in left temporal cerebrocortical blood flow that recovered within 30 seconds, independent of eNOS.
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