February 1, 2001AJP Heart and Circulatory Physiology

Regional differences in mechanisms of cerebral circulatory response to neuronal activation

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Why the study?

Do adenosine and nitric oxide mediate the cerebral blood flow response to neuronal activation in unanesthetized rats?

Structured PICO

Do adenosine and nitric oxide mediate the cerebral blood flow response to neuronal activation in unanesthetized rats?

Population

Unanesthetized rats

Intervention

Adenosine receptor blockade with caffeine or NO synthase inhibition with N(G)-nitro-L-arginine methyl ester (L-NAME) or 7-nitroindazole (7-NI), alone or in combination, during unilateral vibrissal stimulation

Comparator

Baseline/unblocked state

Outcome

Local cerebral blood flow (CBF) in the ipsilateral spinal and principal sensory trigeminal nuclei and contralateral ventroposteromedial (VPM) thalamic nucleus and barrel cortexsurrogate

Adenosine and nitric oxide play regionally distinct roles in mediating cerebral blood flow increases during neuronal activation, but other mechanisms are also involved.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Regionally distinct adenosine and NO roles in rat neurovascular coupling leave open additional mediators and human relevance.

Cite This Study

Gotoh et al. (2001) studied this question.

synapsesocial.com/papers/6a7041b2e36a167817e20201 https://doi.org/10.1152/ajpheart.2001.280.2.h821

View Full Paper

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Regional differences in mechanisms of cerebral circulatory response to neuronal activation

Structured PICO

Discussion

Implication

Cite This Study

Regional differences in mechanisms of cerebral circulatory response to neuronal activation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider