January 1, 1994Journal of Cerebral Blood Flow & Metabolism

Importance of Nitric Oxide Synthase Inhibition to the Attenuated Vascular Responses Induced by Topical L-Nitroarginine during Vibrissal Stimulation

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Why the study?

Does topical L-nitroarginine reduce regional cerebral blood flow response to vibrissal stimulation in anesthetized Sprague-Dawley rats?

Population

Anesthetized Sprague-Dawley rats

Comparison

Topical application of L-nitroarginine through a… vs Baseline (before NOS inhibitor application)

Design

Preclinical

Authors

KIKatsumi IrikuraTokai University Hospital KMKenneth I. MaynardLaunchpad Central (United States)MMMichael A. MoskowitzUniversity of Iowa

Discussion

Member takes

Implication

Supports nitric oxide mediation of neurovascular coupling in rats; leaves open translation to human cerebral blood flow regulation.

Structured PICO

Does topical L-nitroarginine reduce regional cerebral blood flow response to vibrissal stimulation in anesthetized Sprague-Dawley rats?

Population

Anesthetized Sprague-Dawley rats

Intervention

Topical application of L-nitroarginine (1 mM) through a closed cranial window

Comparator

Baseline (before NOS inhibitor application)

Outcome

Regional cerebral blood flow (rCBF) response to vibrissal stimulationsurrogate

Nitric oxide generated from parenchymal NOS activity plays an important role in the cerebrovascular response to physiologic somatosensory stimulation.

Cite This Study

Irikura et al. (1994) studied this question.

synapsesocial.com/papers/6a7445cb51ce19f076092ece https://doi.org/10.1038/jcbfm.1994.7

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Importance of Nitric Oxide Synthase Inhibition to the Attenuated Vascular Responses Induced by Topical L-Nitroarginine during Vibrissal Stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Importance of Nitric Oxide Synthase Inhibition to the Attenuated Vascular Responses Induced by Topical L-Nitroarginine during Vibrissal Stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider