What question did this study set out to answer?

To determine the contribution of nitric oxide synthesis to the increase in cortical blood flow elicited by cerebrovascular parasympathetic nerve stimulation.

November 1, 1993Journal of Cerebral Blood Flow & MetabolismOpen Access

Inhibition of Nitric Oxide Synthase Attenuates the Cerebral Blood Flow Response to Stimulation of Postganglionic Parasympathetic Nerves in the Rat

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To determine the contribution of nitric oxide synthesis to the increase in cortical blood flow elicited by cerebrovascular parasympathetic nerve stimulation.
Monitored cortical blood flow in rats using laser-Doppler flowmetry during electrical stimulation of postganglionic parasympathetic nerves.
Administered the nitric oxide synthase inhibitor L-NAME intravenously at doses of 5 mg/kg or 50 mg/kg across varying exposure durations (10 and 30 minutes).
Infused L-arginine following nitric oxide synthase blockade to test reversibility of the attenuated blood flow response.
Thirty-minute exposure to 50 mg/kg L-NAME eliminated most of the parasympathetic flow response, dropping the cortical blood flow increase from 104% to 8%.
Controlling for the systemic blood pressure increase caused by high-dose L-NAME further unmasked the reduction, leaving only a 3% increase in cortical blood flow.
L-arginine infusion restored the flow response, whereas resting cortical blood flow remained substantially unaffected by nitric oxide synthesis blockade.

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Implication

Hypothesis-generating for nitric oxide in neurogenic cerebral vasodilation; prospective human studies needed before clinical translation.

Cite This Study

Morita-Tsuzuki et al. (1993) studied this question.

synapsesocial.com/papers/6a7a6581bdf697b3de029fe2 https://doi.org/10.1038/jcbfm.1993.124

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Inhibition of Nitric Oxide Synthase Attenuates the Cerebral Blood Flow Response to Stimulation of Postganglionic Parasympathetic Nerves in the Rat

Key Points

Discussion

Implication

Cite This Study

Inhibition of Nitric Oxide Synthase Attenuates the Cerebral Blood Flow Response to Stimulation of Postganglionic Parasympathetic Nerves in the Rat

Key Points

Discussion

Implication

Cite This Study

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