November 1, 1992AJP Regulatory Integrative and Comparative Physiology

Nitric oxide participates in the cerebrovasodilation elicited from cerebellar fastigial nucleus

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Structured PICO

Population

Rats anesthetized with halothane, ventilated, with spinal cord transection to prevent hypertension

Intervention

Superfusion with guanylyl cyclase inhibitor methylene blue (MB) (1 mM) or NO-synthase inhibitor nitro-L-arginine (L-NA) during cerebellar fastigial nucleus (FN) or pontine reticular formation (PRF) stimulation

Comparator

Superfusion with Ringer solution or inactive isomer D-NA

Outcome

Cerebral blood flow (CBF) measured continuously by a laser-Doppler probesurrogate

Nitric oxide mediates the cerebrovasodilation elicited by stimulation of the cerebellar fastigial nucleus in rats.

Discussion

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Implication

NO mediates FN-elicited cerebrovasodilation in rats; leaves open translation to human CBF regulation.

Cite This Study

Costantino Iadecola (1992) studied this question.

synapsesocial.com/papers/6a7445cb51ce19f076092ed1 https://doi.org/10.1152/ajpregu.1992.263.5.r1156

View Full Paper

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Nitric oxide participates in the cerebrovasodilation elicited from cerebellar fastigial nucleus

Structured PICO

Discussion

Implication

Cite This Study

Nitric oxide participates in the cerebrovasodilation elicited from cerebellar fastigial nucleus

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider