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June 1, 1974Acta Anaesthesiologica Scandinavica

Pulmonary Microembolism During Intramedullary Orthopaedic Trauma

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Key result

During prosthetic hip surgery, impaction of the femoral prosthesis caused a significant drop in arterial oxygen tension that strongly correlated (r = -0.97) with lung 125I deposition.

Why the study?

Does prosthetic hip surgery by the Charnley method induce pulmonary microembolism and dysfunction in patients?

Population

Patients undergoing prosthetic hip surgery by the Charnley method

Design

Cohort

Follow-up

Intraoperative

Authors

JMJ. ModigUppsala UniversityCBC. BuschDuke UniversitySOS OlerudSprint (United States)

Discussion

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Implication

May indicate microembolic hypoxemia during hip arthroplasty; hypothesis-generating and should not yet change practice.

Study Design

Type

Observational

Structured PICO

Does prosthetic hip surgery by the Charnley method induce pulmonary microembolism and dysfunction in patients?

P
Population
Patients undergoing prosthetic hip surgery by the Charnley method monitored for pulmonary microembolism during the surgical procedure.
E
Exposure
Administration of 51Cr labelled platelets and 125I labelled fibrinogen the day before operation, with external monitoring of radioactivity over the right lung during surgery
O
Outcome
Accumulation of 51Cr and 125I radioactivity over the right lung and changes in arterial oxygen tension (PaO2) during surgerysurrogate

Main Result

Effect estimate: Correlation coefficient -0.97

Prosthetic hip surgery by the Charnley method is associated with intraoperative pulmonary microembolism and a significant reduction in arterial oxygen tension.

Cite This Study

Modig et al. (1974) conducted an observational in Prosthetic hip surgery. Prosthetic hip surgery (Charnley method) was evaluated on Deposition of 125I radioactivity in the lung and arterial oxygen tension (PaO2) reduction (Correlation coefficient -0.97). During prosthetic hip surgery, impaction of the femoral prosthesis caused a significant drop in arterial oxygen tension that strongly correlated (r = -0.97) with lung 125I deposition.

synapsesocial.com/papers/6a1eb2e4eed4f0c78fa42621https://doi.org/10.1111/j.1399-6576.1974.tb00852.x

Topics

Pulmonary embolism
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sudden Pulmonary Dysfunction in Prosthetic Hip Replacement Surgery: A Case Report1973 · 29 citations
  2. 2Determination of Fibrinogen and Fibrinogenolytic Activity1962 · 219 citations