Key result
During cemented hip arthroplasty, thrombin generation peaked prior to cement introduction, while MMA levels reached a mean of 3599 ng/ml 30 seconds after femoral impaction of cement.
Why the study?
What are the sequential changes in thrombin-antithrombin and methylmethacrylate monomer concentrations during cemented hip arthroplasty?
Population
8 consecutive patients undergoing cemented hip arthroplasty
Design
Case_series
Follow-up
Peroperative
Authors
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Suggests pre-cement thrombin generation in hip arthroplasty; hypothesis-generating for embolic risk mitigation strategies.
Observational (n=8)
What are the sequential changes in thrombin-antithrombin and methylmethacrylate monomer concentrations during cemented hip arthroplasty?
Coagulation is activated prior to bone cement implantation during hip arthroplasty, with evidence of thrombin generation in the pulmonary capillary bed and rapid MMA elimination during lung passage.
Dahl et al. (1992) conducted an observational in Cemented hip arthroplasty (n=8). Cemented hip arthroplasty was evaluated on Thrombin-antithrombin (TAT) and methylmethacrylate monomer (MMA) concentrations. During cemented hip arthroplasty, thrombin generation peaked prior to cement introduction, while MMA levels reached a mean of 3599 ng/ml 30 seconds after femoral impaction of cement.
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