Key result
Injection of methylmethacrylate monomer caused a marked, dose-dependent increase in mean pulmonary arterial blood pressure and a transient fall in mean arterial blood pressure in experimental models.
Why the study?
Does methylmethacrylate monomer (MMA) exposure induce cardiorespiratory and vascular complications in experimental models?
Population
Experimental models (in vitro and in vivo animal models)
Design
Preclinical
Authors
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MMA monomer may underlie perioperative hemodynamic instability; animal data leave open clinical relevance in hip arthroplasty.
Does methylmethacrylate monomer (MMA) exposure induce cardiorespiratory and vascular complications in experimental models?
Methylmethacrylate monomer used in hip replacement surgery induces significant dose-dependent hemodynamic alterations and cytotoxicity in experimental models, potentially explaining perioperative cardiorespiratory dysfunction.
Dahl et al. (1997) studied Hip replacement surgery. Methylmethacrylate monomer (MMA) was evaluated on Mean pulmonary arterial blood pressure (MPAP) and mean arterial blood pressure (MAP). Injection of methylmethacrylate monomer caused a marked, dose-dependent increase in mean pulmonary arterial blood pressure and a transient fall in mean arterial blood pressure in experimental models.
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