Key result
Angiotensin II down-regulates both AT1 and AT2 receptor subtypes through the AT1 receptor via different mechanisms.
Population
Cultured bovine adrenal cells (BAC), PC12W, and R3T3 cells
Design
Preclinical
Authors
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Hypothesis-generating in animal models; leaves open clinical relevance and need for human validation in cardiovascular disease.
Angiotensin II down-regulates both AT1 and AT2 receptors via the AT1 receptor, but utilizes distinct mechanisms involving transcription inhibition for AT1 and mRNA destabilization for AT2.
Ouali et al. (1997) studied this question. Angiotensin II down-regulates both AT1 and AT2 receptor subtypes through the AT1 receptor via different mechanisms.
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