Why the study?
Does Angiotensin II regulate cortisol production and AT1 receptor mRNA expression in cultured human adrenal fasciculata-reticularis cells?
Does Angiotensin II regulate cortisol production and AT1 receptor mRNA expression in cultured human adrenal fasciculata-reticularis cells?
Angiotensin II directly stimulates cortisol production and negatively regulates AT1 receptor mRNA in human adrenal fasciculata-reticularis cells via the AT1 receptor, challenging the classical concept that only glomerulosa cells are targeted by A-II.
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Challenges classical view of A-II targeting only glomerulosa; leaves open in vivo cortisol effects of AT1 blockade.
Naville et al. (1993) studied this question.
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