Key result
Higher heart rate recovery was linearly associated with a lower risk of prevalent hypertension, with each standard deviation increase reducing risk by 35% (OR 0.65; 95% CI 0.48-0.87; P=0.004).
Why the study?
Delayed heart rate recovery indicates autonomic nervous dysfunction, a primary mechanism of hypertension, motivating an evaluation of its independent association with prevalent hypertension.
Is delayed heart rate recovery associated with prevalent hypertension in inpatients?
Cross-Sectional (n=314)
Is delayed heart rate recovery associated with prevalent hypertension in inpatients?
Odds Ratio: 0.65 (95% CI 0.48–0.87)
p-value: p=0.004
Delayed heart rate recovery is independently and linearly associated with an increased risk of prevalent hypertension, suggesting its potential utility in hypertension risk stratification.
Heart rate recovery may aid inpatient hypertension risk stratification; hypothesis-generating and requires prospective validation.
Objectives: Delayed heart rate recovery (HRR) is considered an indicator of autonomic nervous dysfunction, which is a primary pathological mechanism of hypertension. The present study aimed to explore the independent association between delayed HRR and prevalent hypertension.Methods: In this cross-sectional study, 314 inpatients were recruited between January 2018 and December 2019. HRR was defined as the peak heart rate during exercise minus the 2nd-minute heart rate after exercise in the treadmill exercise test.Results: The mean HRR in the hypertension group was lower than that in the non-hypertension group (41 bpm vs. 46 bpm; P < 0.001). After full adjustment, each standard deviation increase in HRR was associated with a 35% decrease in the risk of prevalent hypertension (OR: 0.65, 95% CI: 0.48–0.87; P = 0.004). When the HRR was divided into quartiles, the risk in the top quartile was 26% of that in the bottom quartile (OR: 0.26, 95% CI: 0.12–0.56; P = 0.001). Furthermore, smooth curve fitting showed that the risk of prevalent hypertension decreased linearly with the increase in HRR.Conclusion: Delayed HRR was independently associated with prevalent hypertension. The association was linear and robust over the entire range of HRR. The present study suggested that delayed HRR could be used to optimize hypertension risk stratification.
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Lou et al. (2020) conducted a cross-sectional in Hypertension (n=314). Heart rate recovery (HRR) vs. Lower heart rate recovery was evaluated on Prevalent hypertension (OR 0.65, 95% CI 0.48-0.87, p=0.004). Higher heart rate recovery was linearly associated with a lower risk of prevalent hypertension, with each standard deviation increase reducing risk by 35% (OR 0.65; 95% CI 0.48-0.87; P=0.004).
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